הנדסת נוגדנים (0453.3388)

שם הקורס באנגלית: Antibody Engineering

 

מרצה הקורס: פרופ' בנהר איתי

 

ימים ושעות הקורס

סוג: שיעור
מספר קורס סמסטר יום משעה עד שעה בניין חדר
0453.3388.01 א ה 10:00 12:00 שרמן 105

 

סילבוס:
 
Antibody engineering profession, the key discoveries that shaped it to what it is today. Many of the principles we cover are relevant to biotechnology and in particular, to drug-discovery and development in general.

During the 13 lectures, 2 hours each, the following topics will be discussed.

1) Introduction to Antibody Engineering. The entire field at a glance.
2) The generation of diversity and the tools for studying antibody repertoires.
3) Antibody structure, the immunoglobulin fold and the structure-function correlates of antibodies.
4) Bioinformatic tools and databases for studying antibodies.
5) Cloning antibody genes and expression of antibodies in bacteria.
6) Antibody humanization and de-immunization.
7) Stabilization of antibodies.
8) Isolating human antibodies from transgenic animals.
9) Antibody discovery by display technologies.
10) Armed antibodies; antibody-drug conjugates, immunotoxins, radio-immuno-conjugates.
 
 
דרישות קדם: אימונולוגיה כללית
 
נוכחות חובה
 
הרכב ציון: 
The final grade is based on a multiple-choice exam (3 hours) containing 40 questions. Written materials are allowed in the exam but not any electronic devices.
 
מטלת סיום: בחינה בכתב
 
אוניברסיטת תל-אביב, ת.ד. 39040, תל-אביב 6997801
Developed by
Design by
Basch Interactive